About 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) is a protein
from Homo sapiens identified by UniProt accession
P56937, 341 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 |
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| UniProt accession | P56937 |
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| Gene | HSD17B7 |
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| Organism | Homo sapiens |
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| Length | 341 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- protein measurement · score 0.14
- leukocyte count · score 0.10
- sitting height measurement · score 0.07
- Dupuytren Contracture · score 0.04
- metaphyseal dysplasia without hypotrichosis · score 0.04
- Metaphyseal chondrodysplasia, Schmid type · score 0.03
- spondyloepimetaphyseal dysplasia, Isidor-Toutain type · score 0.03
- Meckel syndrome, type 4 · score 0.03
- open-angle glaucoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56937-F1 | alphafold | PREDICTED | 90.28 | — |
Amino-acid sequence (341 residues)
MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA EGLLTQGDKI TADGLQEVFE TNVFGHFILI RELEPLLCHS DNPSQLIWTS SRSARKSNFS LEDFQHSKGK EPYSSSKYAT DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW TLLMPAILLL RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L
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