Transmembrane protease serine 3 (TMPRSS3)

About Transmembrane protease serine 3

Transmembrane protease serine 3 (TMPRSS3) is a protein from Homo sapiens identified by UniProt accession P57727, 454 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Transmembrane protease serine 3
UniProt accession	P57727
Gene	TMPRSS3
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

hearing loss, autosomal recessive · score 0.66
deafness · score 0.58
nonsyndromic genetic hearing loss · score 0.58
Rare genetic deafness · score 0.53
autosomal dominant nonsyndromic hearing loss · score 0.48
Hearing impairment · score 0.48
genetic disorder · score 0.41
hearing loss · score 0.40
Abnormality of the ear · score 0.27
ear malformation · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57727-F1	alphafold	PREDICTED	86.62	—

Amino-acid sequence (454 residues)

MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards