About Signal recognition particle subunit SRP54
Signal recognition particle subunit SRP54 (SRP54) is a protein
from Homo sapiens identified by UniProt accession
P61011, 504 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Signal recognition particle subunit SRP54 |
|---|
| UniProt accession | P61011 |
|---|
| Gene | SRP54 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 504 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- neutropenia, severe congenital, 8, autosomal dominant · score 0.67
- neurodegenerative disease · score 0.54
- Shwachman-Diamond syndrome · score 0.45
- genetic disorder · score 0.37
- heel bone mineral density · score 0.31
- bone quantitative ultrasound measurement · score 0.28
- BMI-adjusted hip circumference · score 0.24
- type 2 diabetes mellitus · score 0.24
- bone density · score 0.23
- HbA1c measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61011-F1 | alphafold | PREDICTED | 79.25 | — |
Amino-acid sequence (504 residues)
MVLADLGRKI TSALRSLSNA TIINEEVLNA MLKEVCTALL EADVNIKLVK QLRENVKSAI DLEEMASGLN KRKMIQHAVF KELVKLVDPG VKAWTPTKGK QNVIMFVGLQ GSGKTTTCSK LAYYYQRKGW KTCLICADTF RAGAFDQLKQ NATKARIPFY GSYTEMDPVI IASEGVEKFK NENFEIIIVD TSGRHKQEDS LFEEMLQVAN AIQPDNIVYV MDASIGQACE AQAKAFKDKV DVASVIVTKL DGHAKGGGAL SAVAATKSPI IFIGTGEHID DFEPFKTQPF ISKLLGMGDI EGLIDKVNEL KLDDNEALIE KLKHGQFTLR DMYEQFQNIM KMGPFSQILG MIPGFGTDFM SKGNEQESMA RLKKLMTIMD SMNDQELDST DGAKVFSKQP GRIQRVARGS GVSTRDVQEL LTQYTKFAQM VKKMGGIKGL FKGGDMSKNV SQSQMAKLNQ QMAKMMDPRV LHHMGGMAGL QSMMRQFQQG AAGNMKGMMG FNNM
Explore Signal recognition particle subunit SRP54 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets