Dolichyl-diphosphooligosaccharide--protein…

About Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 (TMEM258) is a protein from Homo sapiens identified by UniProt accession P61165, 79 residues long. MolForge cross-references it against 0 known binders and 248 disease associations.

Target properties

Protein name	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
UniProt accession	P61165
Gene	TMEM258
Organism	Homo sapiens
Length	79 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (248)

Diseases linked to this target (Open Targets).

phosphatidylcholine measurement · score 0.37
phosphatidylethanolamine measurement · score 0.37
phosphatidylinositol measurement · score 0.35
serum metabolite measurement · score 0.34
hemoglobin measurement · score 0.31
fatty acid measurement · score 0.31
triglyceride measurement · score 0.29
lysophosphatidylcholine measurement · score 0.29
lysophosphatidylethanolamine measurement · score 0.26
cholesteryl ester 18:3 measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61165-F1	alphafold	PREDICTED	86.79	—

Amino-acid sequence (79 residues)

MELEAMSRYT SPVNPAVFPH LTVVLLAIGM FFTAWFFVYE VTSTKYTRDI YKELLISLVA SLFMGFGVLF LLLWVGIYV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 (TMEM258)