About Syntaxin-1B
Syntaxin-1B (STX1B) is a protein
from Homo sapiens identified by UniProt accession
P61266, 288 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Syntaxin-1B |
|---|
| UniProt accession | P61266 |
|---|
| Gene | STX1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- Generalized epilepsy with febrile seizures-plus · score 0.79
- genetic disorder · score 0.47
- generalized epilepsy with febrile seizures plus · score 0.45
- Neurodevelopmental disorder · score 0.37
- botulism · score 0.37
- Epileptic encephalopathy · score 0.27
- body mass index · score 0.20
- lean body mass · score 0.20
- fat body mass · score 0.18
- body fat percentage · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61266-F1 | alphafold | PREDICTED | 84.12 | — |
Amino-acid sequence (288 residues)
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
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