Alpha-2,8-sialyltransferase 8F (ST8SIA6)

About Alpha-2,8-sialyltransferase 8F

Alpha-2,8-sialyltransferase 8F (ST8SIA6) is a protein from Homo sapiens identified by UniProt accession P61647, 398 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Alpha-2,8-sialyltransferase 8F
UniProt accession	P61647
Gene	ST8SIA6
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

sleep apnea measurement · score 0.33
emotional symptom measurement · score 0.33
pancreatic adenocarcinoma · score 0.21
Age-related cataract · score 0.14
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
hepatocellular carcinoma · score 0.10
aspartate aminotransferase to alanine aminotransferase ratio · score 0.10
lung adenocarcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61647-F1	alphafold	PREDICTED	85.56	—

Amino-acid sequence (398 residues)

MRPGGALLAL LASLLLLLLL RLLWCPADAP GRARILVEES REATHGTPAA LRTLRSPATA VPRATNSTYL NEKSLQLTEK CKNLQYGIES FSNKTKGYSE NDYLQIITDI QSCPWKRQAE EYANFRAKLA SCCDAVQNFV VSQNNTPVGT NMSYEVESKK EIPIKKNIFH MFPVSQPFVD YPYNQCAVVG NGGILNKSLC GTEIDKSDFV FRCNLPPTTG DVSKDVGSKT NLVTINPSII TLKYGNLKEK KALFLEDIAT YGDAFFLLPA FSFRANTGTS FKVYYTLEES KARQKVLFFH PKYLKDLALF WRTKGVTAYR LSTGLMITSV AVELCKNVKL YGFWPFSKTV EDIPVSHHYY DNKLPKHGFH QMPKEYSQIL QLHMKGILKL QFSKCEVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards