About Syntaxin-binding protein 1
Syntaxin-binding protein 1 (STXBP1) is a protein
from Homo sapiens identified by UniProt accession
P61764, 594 residues long.
MolForge cross-references it against 0 known binders and
205 disease associations.
Target properties
| Protein name | Syntaxin-binding protein 1 |
|---|
| UniProt accession | P61764 |
|---|
| Gene | STXBP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 594 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (205)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 4 · score 0.85
- developmental and epileptic encephalopathy · score 0.73
- Intellectual disability · score 0.59
- genetic disorder · score 0.55
- infantile epilepsy syndrome · score 0.54
- Epileptic encephalopathy · score 0.53
- Global developmental delay · score 0.47
- Seizure · score 0.46
- neurodegenerative disease · score 0.46
- spastic ataxia · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61764-F1 | alphafold | PREDICTED | 90.42 | — |
Amino-acid sequence (594 residues)
MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR AAHVFFTDSC PDALFNELVK SRAAKVIKTL TEINIAFLPY ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC ATLKEYPAVR YRGEYKDNAL LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS TYDKIRIILL YIFLKNGITE ENLNKLIQHA QIPPEDSEII TNMAHLGVPI VTDSTLRRRS KPERKERISE QTYQLSRWTP IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS
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