Small ubiquitin-related modifier 2 (SUMO2)

About Small ubiquitin-related modifier 2

Small ubiquitin-related modifier 2 (SUMO2) is a protein from Homo sapiens identified by UniProt accession P61956, 95 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Small ubiquitin-related modifier 2
UniProt accession	P61956
Gene	SUMO2
Organism	Homo sapiens
Length	95 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
breast adenocarcinoma · score 0.27
low grade glioma · score 0.27
urinary bladder cancer · score 0.18
serum gamma-glutamyl transferase measurement · score 0.17
acute myeloid leukemia · score 0.16
cutaneous melanoma · score 0.10
hepatocellular carcinoma · score 0.10
fragile X-associated tremor/ataxia syndrome · score 0.08
glioblastoma multiforme · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61956-F1	alphafold	PREDICTED	83.84	—

Amino-acid sequence (95 residues)

MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards