U6 snRNA-associated Sm-like protein LSm3 (LSM3)

About U6 snRNA-associated Sm-like protein LSm3

U6 snRNA-associated Sm-like protein LSm3 (LSM3) is a protein from Homo sapiens identified by UniProt accession P62310, 102 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	U6 snRNA-associated Sm-like protein LSm3
UniProt accession	P62310
Gene	LSM3
Organism	Homo sapiens
Length	102 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.23
gut microbiome measurement · score 0.21
dilated cardiomyopathy · score 0.21
monocyte percentage of leukocytes · score 0.20
PR interval · score 0.19
birth weight · score 0.18
Red cell distribution width · score 0.16
Xeroderma pigmentosum complementation group C · score 0.16
neutrophil count · score 0.16
hypertrophic cardiomyopathy · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62310-F1	alphafold	PREDICTED	89.17	—

Amino-acid sequence (102 residues)

MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR VG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards