U6 snRNA-associated Sm-like protein LSm6 (LSM6)

About U6 snRNA-associated Sm-like protein LSm6

U6 snRNA-associated Sm-like protein LSm6 (LSM6) is a protein from Homo sapiens identified by UniProt accession P62312, 80 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	U6 snRNA-associated Sm-like protein LSm6
UniProt accession	P62312
Gene	LSM6
Organism	Homo sapiens
Length	80 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
multiple sclerosis · score 0.53
Parkinson disease · score 0.53
lysosomal storage disease · score 0.53
Alzheimer disease · score 0.53
neuroinflammatory disorder · score 0.27
cortical surface area measurement · score 0.04
anorexia nervosa · score 0.04
bipolar disorder · score 0.04
systolic blood pressure · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62312-F1	alphafold	PREDICTED	91.96	—

Amino-acid sequence (80 residues)

MSLRKQTPSD FLKQIIGRPV VVKLNSGVDY RGVLACLDGY MNIALEQTEE YVNGQLKNKY GDAFIRGNNV LYISTQKRRM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards