About Transcription elongation factor SPT4
Transcription elongation factor SPT4 (SUPT4H1) is a protein
from Homo sapiens identified by UniProt accession
P63272, 117 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Transcription elongation factor SPT4 |
|---|
| UniProt accession | P63272 |
|---|
| Gene | SUPT4H1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 117 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- neurodegenerative disease · score 0.33
- health study participation · score 0.25
- mean corpuscular volume · score 0.22
- prostate carcinoma · score 0.21
- eosinophil percentage of leukocytes · score 0.15
- hypertension · score 0.09
- Blackfan-Diamond anemia · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P63272-F1 | alphafold | PREDICTED | 96.53 | — |
Amino-acid sequence (117 residues)
MALETVPKDL RHLRACLLCS LVKTIDQFEY DGCDNCDAYL QMKGNREMVY DCTSSSFDGI IAMMSPEDSW VSKWQRVSNF KPGVYAVSVT GRLPQGIVRE LKSRGVAYKS RDTAIKT
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