Casein kinase II subunit alpha (CSNK2A1)

About Casein kinase II subunit alpha

Casein kinase II subunit alpha (CSNK2A1) is a protein from Homo sapiens identified by UniProt accession P68400, 391 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	Casein kinase II subunit alpha
UniProt accession	P68400
Gene	CSNK2A1
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (121)

Diseases linked to this target (Open Targets).

Okur-Chung neurodevelopmental syndrome · score 0.76
neurodegenerative disease · score 0.52
genetic disorder · score 0.50
neuroinflammatory disorder · score 0.44
complex neurodevelopmental disorder · score 0.37
syndromic intellectual disability · score 0.37
Neurodevelopmental delay · score 0.34
breast adenocarcinoma · score 0.27
low grade glioma · score 0.27
autism spectrum disorder · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68400-F1	alphafold	PREDICTED	88.94	—

Amino-acid sequence (391 residues)

MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN MMSGISSVPT PSPLGPLAGS PVIAAANPLG MPVPAAAGAQ Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards