Iroquois-class homeodomain protein IRX-6 (IRX6)

About Iroquois-class homeodomain protein IRX-6

Iroquois-class homeodomain protein IRX-6 (IRX6) is a protein from Homo sapiens identified by UniProt accession P78412, 446 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Iroquois-class homeodomain protein IRX-6
UniProt accession	P78412
Gene	IRX6
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

erythrocyte count · score 0.42
hematocrit · score 0.40
hemoglobin measurement · score 0.38
red blood cell density measurement · score 0.36
hypospadias · score 0.30
cutaneous melanoma · score 0.29
nevus count · score 0.29
mean corpuscular hemoglobin concentration · score 0.27
neurodegenerative disease · score 0.22
adolescent idiopathic scoliosis · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78412-F1	alphafold	PREDICTED	54.53	—

Amino-acid sequence (446 residues)

MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA PYDSRLLGSA RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA LNPQYEFKEA AGSFTSSLAQ PGAYYPYERT LGQYQYERYG AVELSGAGRR KNATRETTST LKAWLNEHRK NPYPTKGEKI MLAIITKMTL TQVSTWFANA RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK EVTASQEARG LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR IWSLAHTATA SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC DESSCIPKAF GNPKFALQGL PLNCAPCPRR SEPVVQCQYP SGAEAG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards