Sushi repeat-containing protein SRPX (SRPX)

About Sushi repeat-containing protein SRPX

Sushi repeat-containing protein SRPX (SRPX) is a protein from Homo sapiens identified by UniProt accession P78539, 464 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Sushi repeat-containing protein SRPX
UniProt accession	P78539
Gene	SRPX
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

lymphatic system disease · score 0.42
vein disorder · score 0.42
Varicose veins · score 0.34
Inguinal hernia · score 0.34
Hernia · score 0.33
entropion · score 0.29
Trichiasis · score 0.29
Short stature · score 0.29
glioblastoma · score 0.08
neoplasm · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78539-F1	alphafold	PREDICTED	85.23	—

Amino-acid sequence (464 residues)

MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards