Hepcidin (HAMP)

About Hepcidin

Hepcidin (HAMP) is a protein from Homo sapiens identified by UniProt accession P81172, 84 residues long. MolForge cross-references it against 0 known binders and 678 disease associations.

Target properties

Protein name	Hepcidin
UniProt accession	P81172
Gene	HAMP
Organism	Homo sapiens
Length	84 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (678)

Diseases linked to this target (Open Targets).

hemochromatosis type 2B · score 0.79
hemochromatosis type 2 · score 0.46
hereditary hemochromatosis · score 0.45
neurodegenerative disease · score 0.32
erythrocyte count · score 0.19
mean corpuscular volume · score 0.18
mean corpuscular hemoglobin · score 0.18
genetic disorder · score 0.17
Red cell distribution width · score 0.17
mean corpuscular hemoglobin concentration · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P81172-F1	alphafold	PREDICTED	63.02	—

Amino-acid sequence (84 residues)

MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM PMFQRRRRRD THFPICIFCC GCCHRSKCGM CCKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards