U7 snRNA-associated Sm-like protein LSm11 (LSM11)

About U7 snRNA-associated Sm-like protein LSm11

U7 snRNA-associated Sm-like protein LSm11 (LSM11) is a protein from Homo sapiens identified by UniProt accession P83369, 360 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	U7 snRNA-associated Sm-like protein LSm11
UniProt accession	P83369
Gene	LSM11
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
Aicardi-Goutieres syndrome 8 · score 0.45
Aicardi-Goutières syndrome · score 0.37
mean corpuscular volume · score 0.30
Red cell distribution width · score 0.27
mean reticulocyte volume · score 0.25
mean corpuscular hemoglobin concentration · score 0.11
hair shape measurement · score 0.09
diastolic blood pressure · score 0.08
systolic blood pressure · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P83369-F1	alphafold	PREDICTED	64.29	—

Amino-acid sequence (360 residues)

MEERERGARS AGAGSPARPP SPRLDVSSDS FDPLLALYAP RLPPIPYPNA PCFNNVAEYE SFLRTGVRGG GRGRGRARGA AAGSGVPAAP GPSGRTRRRP DAPAPDPERI QRLRRLMVAK EEGDGAAGAG RRGPGRSRKA PRNVLTRMPL HEGSPLGELH RCIREGVKVN VHIRTFKGLR GVCTGFLVAF DKFWNMALTD VDETYRKPVL GKAYERDSSL TLTRLFDRLK LQDSSKKEAD SKSAVEDSTL SRYSQTSTWK LASVWGRADT GRGSHKRSRS VPSSLQASAR EESRSELSGR TTRTDGSSVG GTFSRATTLS RGQSRKKKRK PKVDYQQVFT RHINQIFIRG ENVLLVHLAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards