About Thioredoxin-like protein 4A
Thioredoxin-like protein 4A (TXNL4A) is a protein
from Homo sapiens identified by UniProt accession
P83876, 142 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Thioredoxin-like protein 4A |
|---|
| UniProt accession | P83876 |
|---|
| Gene | TXNL4A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 142 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- Choanal atresia-deafness-cardiac defects-dysmorphism syndrome · score 0.76
- choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome · score 0.72
- cleft palate · score 0.37
- Cleft palate · score 0.37
- neurodegenerative disease · score 0.17
- genetic disorder · score 0.15
- self reported educational attainment · score 0.11
- aspartate aminotransferase measurement · score 0.08
- hepatocellular carcinoma · score 0.08
- monocyte count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P83876-F1 | alphafold | PREDICTED | 88.54 | — |
Amino-acid sequence (142 residues)
MSYMLPHLHN GWQVDQAILS EEDRVVVIRF GHDWDPTCMK MDEVLYSIAE KVKNFAVIYL VDITEVPDFN KMYELYDPCT VMFFFRNKHI MIDLGTGNNN KINWAMEDKQ EMVDIIETVY RGARKGRGLV VSPKDYSTKY RY
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