About Fanconi anemia group C protein
Fanconi anemia group C protein (FANCC) is a protein
from Homo sapiens identified by UniProt accession
Q00597, 558 residues long.
MolForge cross-references it against 0 known binders and
404 disease associations.
Target properties
| Protein name | Fanconi anemia group C protein |
|---|
| UniProt accession | Q00597 |
|---|
| Gene | FANCC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 558 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (404)
Diseases linked to this target (Open Targets).
- Fanconi anemia complementation group C · score 0.84
- Fanconi anemia · score 0.76
- acute myeloid leukemia · score 0.56
- hereditary neoplastic syndrome · score 0.56
- Inherited cancer-predisposing syndrome · score 0.56
- myelodysplastic syndrome · score 0.51
- breast cancer · score 0.49
- Fanconi anemia complementation group A · score 0.46
- leukemia · score 0.46
- ovarian cancer · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00597-F1 | alphafold | PREDICTED | 82.09 | — |
Amino-acid sequence (558 residues)
MAQDSVDLSC DYQFWMQKLS VWDQASTLET QQDTCLHVAQ FQEFLRKMYE ALKEMDSNTV IERFPTIGQL LAKACWNPFI LAYDESQKIL IWCLCCLINK EPQNSGQSKL NSWIQGVLSH ILSALRFDKE VALFTQGLGY APIDYYPGLL KNMVLSLASE LRENHLNGFN TQRRMAPERV ASLSRVCVPL ITLTDVDPLV EALLICHGRE PQEILQPEFF EAVNEAILLK KISLPMSAVV CLWLRHLPSL EKAMLHLFEK LISSERNCLR RIECFIKDSS LPQAACHPAI FRVVDEMFRC ALLETDGALE IIATIQVFTQ CFVEALEKAS KQLRFALKTY FPYTSPSLAM VLLQDPQDIP RGHWLQTLKH ISELLREAVE DQTHGSCGGP FESWFLFIHF GGWAEMVAEQ LLMSAAEPPT ALLWLLAFYY GPRDGRQQRA QTMVQVKAVL GHLLAMSRSS SLSAQDLQTV AGQGTDTDLR APAQQLIRHL LLNFLLWAPG GHTIAWDVIT LMAHTAEITH EIIGFLDQTL YRWNRLGIES PRSEKLAREL LKELRTQV
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