About Serine/arginine-rich splicing factor 2
Serine/arginine-rich splicing factor 2 (SRSF2) is a protein
from Homo sapiens identified by UniProt accession
Q01130, 221 residues long.
MolForge cross-references it against 0 known binders and
328 disease associations.
Target properties
| Protein name | Serine/arginine-rich splicing factor 2 |
|---|
| UniProt accession | Q01130 |
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| Gene | SRSF2 |
|---|
| Organism | Homo sapiens |
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| Length | 221 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (328)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.73
- myelodysplastic syndrome · score 0.68
- neoplasm · score 0.60
- myeloid leukemia · score 0.58
- lymphoid neoplasm · score 0.57
- hematopoietic and lymphoid system neoplasm · score 0.57
- reticulocyte measurement · score 0.57
- Sepsis · score 0.56
- chronic myelomonocytic leukemia · score 0.56
- myeloid neoplasm · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01130-F1 | alphafold | PREDICTED | 64.32 | — |
Amino-acid sequence (221 residues)
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY TKESRGFAFV RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH SRRGPPPRRY GGGGYGRRSR SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR SRTRSRSRST SKSRSARRSK SKSSSVSRSR SRSRSRSRSR SPPPVSKRES KSRSRSKSPP KSPEEEGAVS S
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