About Adrenocorticotropic hormone receptor
Adrenocorticotropic hormone receptor (MC2R) is a protein
from Homo sapiens identified by UniProt accession
Q01718, 297 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Adrenocorticotropic hormone receptor |
|---|
| UniProt accession | Q01718 |
|---|
| Gene | MC2R |
|---|
| Organism | Homo sapiens |
|---|
| Length | 297 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (186)
Diseases linked to this target (Open Targets).
- familial glucocorticoid deficiency · score 0.74
- multiple sclerosis · score 0.56
- rheumatoid arthritis · score 0.55
- systemic lupus erythematosus · score 0.54
- sarcoidosis · score 0.53
- kidney disease · score 0.52
- nephrotic syndrome · score 0.49
- psoriatic arthritis · score 0.46
- dry eye syndrome · score 0.46
- focal segmental glomerulosclerosis · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01718-F1 | alphafold | PREDICTED | 85.40 | — |
Amino-acid sequence (297 residues)
MKHIINSYEN INNTARNNSD CPRVVLPEEI FFTISIVGVL ENLIVLLAVF KNKNLQAPMY FFICSLAISD MLGSLYKILE NILIILRNMG YLKPRGSFET TADDIIDSLF VLSLLGSIFS LSVIAADRYI TIFHALRYHS IVTMRRTVVV LTVIWTFCTG TGITMVIFSH HVPTVITFTS LFPLMLVFIL CLYVHMFLLA RSHTRKISTL PRANMKGAIT LTILLGVFIF CWAPFVLHVL LMTFCPSNPY CACYMSLFQV NGMLIMCNAV IDPFIYAFRS PELRDAFKKM IFCSRYW
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