Melanocyte-stimulating hormone receptor (MC1R)

About Melanocyte-stimulating hormone receptor

Melanocyte-stimulating hormone receptor (MC1R) is a protein from Homo sapiens identified by UniProt accession Q01726, 317 residues long. MolForge cross-references it against 0 known binders and 376 disease associations.

Target properties

Protein name	Melanocyte-stimulating hormone receptor
UniProt accession	Q01726
Gene	MC1R
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (376)

Diseases linked to this target (Open Targets).

skin pigmentation · score 0.72
hair colour measurement · score 0.66
skin pigmentation measurement · score 0.57
erythropoietic protoporphyria · score 0.53
sun exposure measurement · score 0.51
oculocutaneous albinism type 2 · score 0.49
cutaneous melanoma · score 0.47
hair color · score 0.45
oculocutaneous albinism type 6 · score 0.43
sunburn · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01726-F1	alphafold	PREDICTED	80.51	—

Amino-acid sequence (317 residues)

MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL VSLVENALVV ATIAKNRNLH SPMYCFICCL ALSDLLVSGS NVLETAVILL LEAGALVARA AVLQQLDNVI DVITCSSMLS SLCFLGAIAV DRYISIFYAL RYHSIVTLPR ARRAVAAIWV ASVVFSTLFI AYYDHVAVLL CLVVFFLAML VLMAVLYVHM LARACQHAQG IARLHKRQRP VHQGFGLKGA VTLTILLGIF FLCWGPFFLH LTLIVLCPEH PTCGCIFKNF NLFLALIICN AIIDPLIYAF HSQELRRTLK EVLTCSW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards