About Cytochrome P450 4A11
Cytochrome P450 4A11 (CYP4A11) is a protein
from Homo sapiens identified by UniProt accession
Q02928, 519 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Cytochrome P450 4A11 |
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| UniProt accession | Q02928 |
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| Gene | CYP4A11 |
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| Organism | Homo sapiens |
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| Length | 519 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (155)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.41
- blood metabolite measurement · score 0.35
- urinary metabolite measurement · score 0.27
- cutaneous melanoma · score 0.27
- glioblastoma multiforme · score 0.23
- neurodegenerative disease · score 0.20
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- metabolite measurement · score 0.18
- head and neck squamous cell carcinoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02928-F1 | alphafold | PREDICTED | 91.26 | — |
Amino-acid sequence (519 residues)
MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ FPCPPSHWLF GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY DPDYMKVILG RSDPKSHGSY RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF HYDILKPYVG LMADSVRVML DKWEELLGQD SPLEVFQHVS LMTLDTIMKC AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND TIYSLTSAGR WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE IHSLLGDGAS ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP DGRSLPKGIM VLLSIYGLHH NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF SGGSRNCIGK QFAMNELKVA TALTLLRFEL LPDPTRIPIP IARLVLKSKN GIHLRLRRLP NPCEDKDQL
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