About Tumor necrosis factor alpha-induced protein 2
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) is a protein
from Homo sapiens identified by UniProt accession
Q03169, 654 residues long.
MolForge cross-references it against 0 known binders and
223 disease associations.
Target properties
| Protein name | Tumor necrosis factor alpha-induced protein 2 |
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| UniProt accession | Q03169 |
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| Gene | TNFAIP2 |
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| Organism | Homo sapiens |
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| Length | 654 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (223)
Diseases linked to this target (Open Targets).
- cardiac troponin I measurement · score 0.30
- cathepsin L1 measurement · score 0.30
- gut microbiome measurement · score 0.25
- diffuse plaque measurement · score 0.21
- inflammatory bowel disease · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.12
- mean platelet volume · score 0.12
- platelet count · score 0.12
- acute myeloid leukemia · score 0.09
- alkaline phosphatase measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03169-F1 | alphafold | PREDICTED | 85.31 | — |
Amino-acid sequence (654 residues)
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG
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