About Antigen peptide transporter 2
Antigen peptide transporter 2 (TAP2) is a protein
from Homo sapiens identified by UniProt accession
Q03519, 686 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Antigen peptide transporter 2 |
|---|
| UniProt accession | Q03519 |
|---|
| Gene | TAP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 686 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (102)
Diseases linked to this target (Open Targets).
- MHC class I deficiency · score 0.70
- Immunodeficiency by defective expression of HLA class 1 · score 0.64
- type 1 diabetes mellitus · score 0.27
- autoimmune thyroid disease · score 0.27
- response to vaccine · score 0.26
- complement C4 measurement · score 0.25
- immunoglobulin isotype switching measurement · score 0.25
- tonsillectomy risk measurement · score 0.24
- rheumatoid arthritis · score 0.22
- ACPA-positive rheumatoid arthritis · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03519-F1 | alphafold | PREDICTED | 82.67 | — |
Amino-acid sequence (686 residues)
MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA HRLQTVQRAH QILVLQEGKL QKLAQL
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