About Activin receptor type-1
Activin receptor type-1 (ACVR1) is a protein
from Homo sapiens identified by UniProt accession
Q04771, 509 residues long.
MolForge cross-references it against 0 known binders and
414 disease associations.
Target properties
| Protein name | Activin receptor type-1 |
|---|
| UniProt accession | Q04771 |
|---|
| Gene | ACVR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 509 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (414)
Diseases linked to this target (Open Targets).
- fibrodysplasia ossificans progressiva · score 0.83
- tibia fracture · score 0.50
- neurodegenerative disease · score 0.48
- genetic disorder · score 0.47
- bone disease · score 0.46
- gastric adenocarcinoma · score 0.39
- pancreatic ductal adenocarcinoma · score 0.37
- kidney neoplasm · score 0.37
- malignant glioma · score 0.37
- Brain Stem Glioma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q04771-F1 | alphafold | PREDICTED | 83.11 | — |
Amino-acid sequence (509 residues)
MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN SLDKLKTDC
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