Serine/arginine-rich splicing factor 11 (SRSF11)

About Serine/arginine-rich splicing factor 11

Serine/arginine-rich splicing factor 11 (SRSF11) is a protein from Homo sapiens identified by UniProt accession Q05519, 484 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Serine/arginine-rich splicing factor 11
UniProt accession	Q05519
Gene	SRSF11
Organism	Homo sapiens
Length	484 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
hepatocellular carcinoma · score 0.07
Familial short QT syndrome · score 0.05
self reported educational attainment · score 0.04
cognitive function measurement · score 0.04
mathematical ability · score 0.04
Brugada syndrome · score 0.04
atrial conduction disease · score 0.04
adolescent idiopathic scoliosis · score 0.03
long QT syndrome 15 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05519-F1	alphafold	PREDICTED	55.42	—

Amino-acid sequence (484 residues)

MSNTTVVPST AGPGPSGGPG GGGGGGGGGG GTEVIQVTNV SPSASSEQMR TLFGFLGKID ELRLFPPDDS PLPVSSRVCF VKFHDPDSAV VAQHLTNTVF VDRALIVVPY AEGVIPDEAK ALSLLAPANA VAGLLPGGGL LPTPNPLTQI GAVPLAALGA PTLDPALAAL GLPGANLNSQ SLAADQLLKL MSTVDPKLNH VAAGLVSPSL KSDTSSKEIE EAMKRVREAQ SLISAAIEPD KKEEKRRHSR SRSRSRRRRT PSSSRHRRSR SRSRRRSHSK SRSRRRSKSP RRRRSHSRER GRRSRSTSKT RDKKKEDKEK KRSKTPPKSY STARRSRSAS RERRRRRSRS GTRSPKKPRS PKRKLSRSPS PRRHKKEKKK DKDKERSRDE RERSTSKKKK SKDKEKDRER KSESDKDVKQ VTRDYDEEEQ GYDSEKEKKE EKKPIETGSP KTKECSVEKG TGDSLRESKV NGDDHHEEDM DMSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards