About Nuclear transition protein 2
Nuclear transition protein 2 (TNP2) is a protein
from Homo sapiens identified by UniProt accession
Q05952, 138 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Nuclear transition protein 2 |
|---|
| UniProt accession | Q05952 |
|---|
| Gene | TNP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 138 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (151)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.16
- eosinophil count · score 0.15
- azoospermia · score 0.12
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- ulcerative colitis · score 0.10
- spermatogenic failure 72 · score 0.09
- spermatogenic failure 27 · score 0.09
- spermatogenic failure 46 · score 0.09
- spermatogenic failure 18 · score 0.09
- spermatogenic failure 49 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05952-F1 | alphafold | PREDICTED | 58.72 | — |
Amino-acid sequence (138 residues)
MDTQTHSLPI THTQLHSNSQ PQSRTCTRHC QTFSQSCRQS HRGSRSQSSS QSPASHRNPT GAHSSSGHQS QSPNTSPPPK RHKKTMNSHH SPMRPTILHC RCPKNRKNLE GKLKKKKMAK RIQQVYKTKT RSSGWKSN
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