Leucine-rich repeat-containing protein 63 (LRRC63)

About Leucine-rich repeat-containing protein 63

Leucine-rich repeat-containing protein 63 (LRRC63) is a protein from Homo sapiens identified by UniProt accession Q05C16, 587 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 63
UniProt accession	Q05C16
Gene	LRRC63
Organism	Homo sapiens
Length	587 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

protein measurement · score 0.35
lymphocyte count · score 0.04
bone density · score 0.02
urate measurement · score 0.02
neoplasm · score 0.00
nervous system disease · score 0.00
uterine leiomyosarcoma · score 0.00
chronic myelogenous leukemia · score 0.00
Sjogren syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05C16-F1	alphafold	PREDICTED	59.31	—

Amino-acid sequence (587 residues)

MQKPPLLLRR PLPPKFTKLS LHEKKTHTAK TGKIESLHVA FTEDETTSIK MDRTRFPDVL RNQSLTPINI QNIFLDHCVQ ERVTAISSPQ KSTKHVREQI PDTATGSIFF PHCNSASTRI FGKQTNKMES SRKFKTMKDV YTEKRLENIL ILSSKFSKPK STPGSVIAQK LEKMHPKHQP LPESPGYTYQ HISRDLSATV PSPPPMTVSM KPEGQWPEHF KSTATLTLRV TEFPGFVSLP TPVLPRKPHR QSVIETLVTE NGNIESVPKQ IPPRPPEGLT KTEKIESEIH VVRGEGFKTV AATRYETITA MTNLAIVNCQ VYGRNALNLK GFFILNCPDL TPLAFQLIYL NLSFNDLHYF PTEILCLKNL QILKLRNNPI KEIPSEIQQL EFLRIFTIAF NLITVLPIGL FSLSYLEELD VSYNELTFIP NEIQKLRSLE KLTVDGNELS FFPHGILKLN LTKIQFENNF THPCFWRDNY LNNPQQLTQI ISLFIVQNKL HKFYDKIPVE VQKLLKCTSR CEWCHGPKFG EGFRVIRSCD IFGASQLPVM FYVCSPSCYR RIKESSFVLD GSPSRRIALD VELSKEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards