About Deuterosome assembly protein 1
Deuterosome assembly protein 1 (DEUP1) is a protein
from Homo sapiens identified by UniProt accession
Q05D60, 604 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Deuterosome assembly protein 1 |
|---|
| UniProt accession | Q05D60 |
|---|
| Gene | DEUP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 604 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.32
- HbA1c measurement · score 0.27
- Polycystic Kidney Disease · score 0.11
- Meckel syndrome · score 0.11
- multiple gestation · score 0.08
- papillary thyroid carcinoma · score 0.08
- neoplasm · score 0.07
- hepatocellular carcinoma · score 0.07
- hemoglobin D disease · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05D60-F1 | alphafold | PREDICTED | 77.63 | — |
Amino-acid sequence (604 residues)
MENQAHNTMG TSPCEAELQE LMEQIDIMVS NKKMDWERKM RALETRLDLR DQELANAQTC LDQKGQEVGL LRQKLDSLEK CNLAMTQNYE GQLQSLKAQF SKLTNNFEKL RLHQMKQNKV PRKELPHLKE EIPFELSNLN QKLEEFRAKS REWDKQEILY QTHLISLDAQ QKLLSEKCNQ FQKQAQSYQT QLNGKKQCLE DSSSEIPRLI CDPDPNCEIN ERDEFIIEKL KSAVNEIALS RNKLQDENQK LLQELKMYQR QCQAMEAGLS EVKSELQSRD DLLRIIEMER LQLHRELLKI GECQNAQGNK TRLESSYLPS IKEPERKIKE LFSVMQDQPN HEKELNKIRS QLQQVEEYHN SEQERMRNEI SDLTEELHQK EITIATVTKK AALLEKQLKM ELEIKEKMLA KQKVSDMKYK AVRTENTHLK GMMGDLDPGE YMSMDFTNRE QSRHTSINKL QYENERLRND LAKLHVNGKS TWTNQNTYEE TGRYAYQSQI KVEQNEERLS HDCEPNRSTM PPLPPSTFQA KEMTSPLVSD DDVFPLSPPD MSFPASLAAQ HFLLEEEKRA KELEKLLNTH IDELQRHTEF TLNKYSKLKQ NRHI
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