About Tyrosine-protein kinase BTK
Tyrosine-protein kinase BTK (BTK) is a protein
from Homo sapiens identified by UniProt accession
Q06187, 659 residues long.
MolForge cross-references it against 0 known binders and
784 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase BTK |
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| UniProt accession | Q06187 |
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| Gene | BTK |
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| Organism | Homo sapiens |
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| Length | 659 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (784)
Diseases linked to this target (Open Targets).
- X-linked agammaglobulinemia · score 0.84
- Non-acquired isolated growth hormone deficiency · score 0.75
- Bruton-type agammaglobulinemia · score 0.73
- chronic lymphocytic leukemia · score 0.71
- Mantle cell lymphoma · score 0.69
- isolated growth hormone deficiency type III · score 0.58
- Waldenstrom macroglobulinemia · score 0.55
- isolated agammaglobulinemia · score 0.55
- neoplasm · score 0.53
- agammaglobulinemia · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06187-F1 | alphafold | PREDICTED | 84.45 | — |
Amino-acid sequence (659 residues)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER FTNSETAEHI AQGLRLYRPH LASEKVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES
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