About Lymphotoxin-beta
Lymphotoxin-beta (LTB) is a protein
from Homo sapiens identified by UniProt accession
Q06643, 244 residues long.
MolForge cross-references it against 0 known binders and
501 disease associations.
Target properties
| Protein name | Lymphotoxin-beta |
|---|
| UniProt accession | Q06643 |
|---|
| Gene | LTB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 244 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (501)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- lymphoid neoplasm · score 0.33
- rheumatoid arthritis · score 0.10
- blood protein measurement · score 0.10
- hyper-IgM syndrome type 2 · score 0.09
- hyper-IgM syndrome type 3 · score 0.08
- severe combined immunodeficiency due to CD70 deficiency · score 0.08
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.08
- hyper-IgM syndrome type 5 · score 0.08
- immunodeficiency 75 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q06643-F1 | alphafold | PREDICTED | 77.20 | — |
Amino-acid sequence (244 residues)
MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA VMVG
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