Sodium channel regulatory subunit beta-1 (SCN1B)

About Sodium channel regulatory subunit beta-1

Sodium channel regulatory subunit beta-1 (SCN1B) is a protein from Homo sapiens identified by UniProt accession Q07699, 218 residues long. MolForge cross-references it against 0 known binders and 259 disease associations.

Target properties

Protein name	Sodium channel regulatory subunit beta-1
UniProt accession	Q07699
Gene	SCN1B
Organism	Homo sapiens
Length	218 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (259)

Diseases linked to this target (Open Targets).

Generalized epilepsy with febrile seizures-plus · score 0.75
developmental and epileptic encephalopathy, 52 · score 0.73
Brugada syndrome · score 0.73
developmental and epileptic encephalopathy · score 0.68
familial atrial fibrillation · score 0.64
Abnormality of the cardiovascular system · score 0.47
Dravet syndrome · score 0.46
generalized epilepsy with febrile seizures plus · score 0.45
cardiac conduction defect · score 0.44
conduction system disorder · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q07699-F1	alphafold	PREDICTED	87.09	—

Amino-acid sequence (218 residues)

MGRLLALVVG AALVSSACGG CVEVDSETEA VYGMTFKILC ISCKRRSETN AETFTEWTFR QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYE CHVYRLLFFE NYEHNTSVVK KIHIEVVDKA NRDMASIVSE IMMYVLIVVL TIWLVAEMIY CYKKIAAATE TAAQENASEY LAITSESKEN CTGVQVAE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards