About TLE family member 5
TLE family member 5 (TLE5) is a protein
from Homo sapiens identified by UniProt accession
Q08117, 197 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | TLE family member 5 |
|---|
| UniProt accession | Q08117 |
|---|
| Gene | TLE5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 197 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (77)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.34
- blood protein measurement · score 0.23
- IGF-1 measurement · score 0.18
- blood phosphate measurement · score 0.16
- monocyte percentage of leukocytes · score 0.12
- short stature due to GHSR deficiency · score 0.06
- Non-acquired isolated growth hormone deficiency · score 0.05
- non-acquired combined pituitary hormone deficiency with spine abnormalities · score 0.05
- panhypopituitarism · score 0.05
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08117-F1 | alphafold | PREDICTED | 74.14 | — |
Amino-acid sequence (197 residues)
MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK NGHDGDTHQE DDGEKSD
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