Serine/arginine-rich splicing factor 4 (SRSF4)

About Serine/arginine-rich splicing factor 4

Serine/arginine-rich splicing factor 4 (SRSF4) is a protein from Homo sapiens identified by UniProt accession Q08170, 494 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Serine/arginine-rich splicing factor 4
UniProt accession	Q08170
Gene	SRSF4
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.26
hematocrit · score 0.22
urate measurement · score 0.20
mean corpuscular volume · score 0.15
low density lipoprotein cholesterol measurement · score 0.15
mean reticulocyte volume · score 0.14
diastolic blood pressure · score 0.12
HbA1c measurement · score 0.11
wellbeing measurement · score 0.08
alcohol consumption measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q08170-F1	alphafold	PREDICTED	56.15	—

Amino-acid sequence (494 residues)

MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD AVYELNGKDL CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT RTEYRLIVEN LSSRCSWQDL KDYMRQAGEV TYADAHKGRK NEGVIEFVSY SDMKRALEKL DGTEVNGRKI RLVEDKPGSR RRRSYSRSRS HSRSRSRSRH SRKSRSRSGS SKSSHSKSRS RSRSGSRSRS KSRSRSQSRS RSKKEKSRSP SKEKSRSRSH SAGKSRSKSK DQAEEKIQNN DNVGKPKSRS PSRHKSKSKS RSRSQERRVE EEKRGSVSRG RSQEKSLRQS RSRSRSKGGS RSRSRSRSKS KDKRKGRKRS REESRSRSRS RSKSERSRKR GSKRDSKAGS SKKKKKEDTD RSQSRSPSRS VSKEREHAKS ESSQREGRGE SENAGTNQET RSRSRSNSKS KPNLPSESRS RSKSASKTRS RSKSRSRSAS RSPSRSRSRS HSRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards