About 3',5'-cyclic-AMP phosphodiesterase 4C
3',5'-cyclic-AMP phosphodiesterase 4C (PDE4C) is a protein
from Homo sapiens identified by UniProt accession
Q08493, 712 residues long.
MolForge cross-references it against 0 known binders and
224 disease associations.
Target properties
| Protein name | 3',5'-cyclic-AMP phosphodiesterase 4C |
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| UniProt accession | Q08493 |
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| Gene | PDE4C |
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| Organism | Homo sapiens |
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| Length | 712 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (224)
Diseases linked to this target (Open Targets).
- asthma · score 0.60
- chronic obstructive pulmonary disease · score 0.59
- psoriasis · score 0.59
- atopic eczema · score 0.58
- Airway obstruction · score 0.58
- psoriatic arthritis · score 0.57
- coronary artery disease · score 0.55
- stroke · score 0.55
- chronic bronchitis · score 0.54
- chronic kidney disease · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08493-F1 | alphafold | PREDICTED | 71.14 | — |
Amino-acid sequence (712 residues)
MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP DKSAGCRERD LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQSS PGLGRIMQAP VPHSQRRESF LYRSDSDYEL SPKAMSRNSS VASDLHGEDM IVTPFAQVLA SLRTVRSNVA ALARQQCLGA AKQGPVGNPS SSNQLPPAED TGQKLALETL DELDWCLDQL ETLQTRHSVG EMASNKFKRI LNRELTHLSE TSRSGNQVSE YISRTFLDQQ TEVELPKVTA EEAPQPMSRI SGLHGLCHSA SLSSATVPRF GVQTDQEEQL AKELEDTNKW GLDVFKVAEL SGNRPLTAII FSIFQERDLL KTFQIPADTL ATYLLMLEGH YHANVAYHNS LHAADVAQST HVLLATPALE AVFTDLEILA ALFASAIHDV DHPGVSNQFL INTNSELALM YNDASVLENH HLAVGFKLLQ AENCDIFQNL SAKQRLSLRR MVIDMVLATD MSKHMNLLAD LKTMVETKKV TSLGVLLLDN YSDRIQVLQN LVHCADLSNP TKPLPLYRQW TDRIMAEFFQ QGDRERESGL DISPMCDKHT ASVEKSQVGF IDYIAHPLWE TWADLVHPDA QDLLDTLEDN REWYQSKIPR SPSDLTNPER DGPDRFQFEL TLEEAEEEDE EEEEEGEETA LAKEALELPD TELLSPEAGP DPGDLPLDNQ RT
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