About Testican-1
Testican-1 (SPOCK1) is a protein
from Homo sapiens identified by UniProt accession
Q08629, 439 residues long.
MolForge cross-references it against 0 known binders and
198 disease associations.
Target properties
| Protein name | Testican-1 |
|---|
| UniProt accession | Q08629 |
|---|
| Gene | SPOCK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 439 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (198)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.46
- attention deficit hyperactivity disorder · score 0.26
- substance abuse · score 0.26
- antisocial behaviour measurement · score 0.26
- mathematical ability · score 0.22
- allergic disease · score 0.17
- neoplasm · score 0.11
- Microcephaly · score 0.11
- hemoglobin measurement · score 0.11
- cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08629-F1 | alphafold | PREDICTED | 64.00 | — |
Amino-acid sequence (439 residues)
MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ YDRDKYWNRF RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ DYQTALCVSR KHLLPRQKKG NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS DGHSYTSKCK LEFHACSTGK SLATLCDGPC PCLPEPEPPK HKAERSACTD KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS ILPICKDSLG WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG STGQCWCVDK YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY ERELGPKDKE GKLRVHTRAV TEDDEDEDDD KEDEVGYIW
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