About Transmembrane protein 62
Transmembrane protein 62 (TMEM62) is a protein
from Homo sapiens identified by UniProt accession
Q0P6H9, 643 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Transmembrane protein 62 |
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| UniProt accession | Q0P6H9 |
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| Gene | TMEM62 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.11
- high density lipoprotein cholesterol measurement · score 0.08
- Familial short QT syndrome · score 0.07
- Romano-Ward syndrome · score 0.07
- Brugada syndrome · score 0.07
- familial atrial fibrillation · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
- Familial progressive cardiac conduction defect · score 0.06
- hypertrophic cardiomyopathy · score 0.06
- sinoatrial node dysfunction and deafness · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0P6H9-F1 | alphafold | PREDICTED | 91.76 | — |
Amino-acid sequence (643 residues)
MAAVLALRVV AGLAAAALVA MLLEHYGLAG QPSPLPRPAP PRRPHPAPGP GDSNIFWGLQ ISDIHLSRFR DPGRAVDLEK FCSETIDIIQ PALVLATGDL TDAKTKEQLG SRQHEVEWQT YQGILKKTRV MEKTKWLDIK GNHDAFNIPS LDSIKNYYRK YSAVRRDGSF HYVHSTPFGN YSFICVDATV NPGPKRPYNF FGILDKKKME ELLLLAKESS RSNHTIWFGH FTTSTILSPS PGIRSIMSSA IAYLCGHLHT LGGLMPVLHT RHFQGTLELE VGDWKDNRRY RIFAFDHDLF SFADLIFGKW PVVLITNPKS LLYSCGEHEP LERLLHSTHI RVLAFSLSSI TSVTVKIDGV HLGQAVHVSG PIFVLKWNPR NYSSGTHNIE VIVQDSAGRS KSVHHIFSVQ ENNHLSFDPL ASFILRTDHY IMARVLFVLI VLSQLTILII FRYRGYPELK EPSGFINLTS FSLHVLSKIN IFYYSVLLLT LYTVLGPWFF GEIIDGKFGC CFSFGIFVNG HFLQGSITFI IGILQLAFFN IPLMAYMCWS LLQRCFGHNF RSHLHQRKYL KIMPVHLLML LLYIWQVYSC YFLYATYGTL AFLFSPLRTW LTLLTPVLIR YVWTLNSTKF GIFMVQLKSH LSS
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