Leucine-rich repeat-containing protein 74A (LRRC74A)

About Leucine-rich repeat-containing protein 74A

Leucine-rich repeat-containing protein 74A (LRRC74A) is a protein from Homo sapiens identified by UniProt accession Q0VAA2, 488 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 74A
UniProt accession	Q0VAA2
Gene	LRRC74A
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.42
cervical cancer · score 0.09
atrial fibrillation · score 0.06
total blood protein measurement · score 0.04
blood protein measurement · score 0.04
urate measurement · score 0.04
bone density · score 0.04
protein measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q0VAA2-F1	alphafold	PREDICTED	83.67	—

Amino-acid sequence (488 residues)

MHIQFPSKPT LPRACWEGRI TAGSPGMPPD EIEIEPVRQS SDKMLYCEAE SPPTVEKVKP ARENSETDLE IEDDEKFFTT GQKELYLEAC KLMGVVPVSY FIRNMEESYV NLNHHGLGPR GTKAIAIALV SNMAVTKLEL EDNCIMEEGV LSLVEMLQEN YYLQEMNISN NHLGLEGARI ISDFFERNSS SIWSLELSGN DFKEDSAALL CQALSTNYQI KKLDLSHNQF SDVGGEHLGQ MLAINVGLTS LDLSWNNFHT RGAVALCNGL RGNVTLTKLD LSMNGFGNEV ALALGEVLRL NRCLVYLDIG GNDIGNEGAS KISKGLESNE SLRVLKLFLN PINMDGAILL ILAIKRNPKS RMEELDISNV LVSEQFMKTL DGVYAVHPQL DVVFKAVQGL SPKKTIFLLT NPMKLIQSYA DQHKITIVDF FKSLNPTGTM KMSVDEFQKV MIEQNKVPLN QYQVREVIKK LDEKTGMVNF SFLNTMKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards