Thyrotroph embryonic factor (TEF)

About Thyrotroph embryonic factor

Thyrotroph embryonic factor (TEF) is a protein from Homo sapiens identified by UniProt accession Q10587, 303 residues long. MolForge cross-references it against 0 known binders and 188 disease associations.

Target properties

Protein name	Thyrotroph embryonic factor
UniProt accession	Q10587
Gene	TEF
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (188)

Diseases linked to this target (Open Targets).

lymphocyte percentage of leukocytes · score 0.29
eosinophil count · score 0.23
eosinophil percentage of leukocytes · score 0.23
lymphocyte count · score 0.22
neurodegenerative disease · score 0.22
IGF-1 measurement · score 0.16
neutrophil percentage of leukocytes · score 0.15
neutrophil percentage of granulocytes · score 0.11
Vitiligo · score 0.11
sum of eosinophil and basophil counts · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q10587-F1	alphafold	PREDICTED	73.31	—

Amino-acid sequence (303 residues)

MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA RLDKEKGKEK LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD LDEFLLENGI PASPTHLAHN LLLPVAELEG KESASSSTAS PPSSSTAIFQ PSETVSSTES SLEKERETPS PIDPNCVEVD VNFNPDPADL VLSSVPGGEL FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR KKNNVAAKRS RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY GPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards