Bone marrow stromal antigen 2 (BST2)

About Bone marrow stromal antigen 2

Bone marrow stromal antigen 2 (BST2) is a protein from Homo sapiens identified by UniProt accession Q10589, 180 residues long. MolForge cross-references it against 0 known binders and 193 disease associations.

Target properties

Protein name	Bone marrow stromal antigen 2
UniProt accession	Q10589
Gene	BST2
Organism	Homo sapiens
Length	180 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (193)

Diseases linked to this target (Open Targets).

severe acute respiratory syndrome · score 0.37
body height · score 0.24
neoplasm · score 0.11
cancer · score 0.11
infect · score 0.11
infection · score 0.11
breast cancer · score 0.10
oral squamous cell carcinoma · score 0.10
Systemic lupus erythematosus · score 0.08
experimental autoimmune encephalomyelitis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q10589-F1	alphafold	PREDICTED	85.35	—

Amino-acid sequence (180 residues)

MASTSYDYCR VPMEDGDKRC KLLLGIGILV LLIIVILGVP LIIFTIKANS EACRDGLRAV MECRNVTHLL QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS SSAAAPQLLI VLLGLSALLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards