About CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) is a protein
from Homo sapiens identified by UniProt accession
Q11201, 340 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 |
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| UniProt accession | Q11201 |
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| Gene | ST3GAL1 |
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| Organism | Homo sapiens |
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| Length | 340 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.46
- blood protein measurement · score 0.43
- aspartate aminotransferase measurement · score 0.42
- IGF-1 measurement · score 0.42
- body height · score 0.38
- severe acute respiratory syndrome · score 0.37
- body weight · score 0.31
- frontal fibrosing alopecia · score 0.31
- lean body mass · score 0.30
- whole body water mass · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q11201-F1 | alphafold | PREDICTED | 90.05 | — |
Amino-acid sequence (340 residues)
MVTLRKRTLK VLTFLVLFIF LTSFFLNYSH TMVATTWFPK QMVLELSENL KRLIKHRPCT CTHCIGQRKL SAWFDERFNQ TMQPLLTAQN ALLEDDTYRW WLRLQREKKP NNLNDTIKEL FRVVPGNVDP MLEKRSVGCR RCAVVGNSGN LRESSYGPEI DSHDFVLRMN KAPTAGFEAD VGTKTTHHLV YPESFRELGD NVSMILVPFK TIDLEWVVSA ITTGTISHTY IPVPAKIRVK QDKILIYHPA FIKYVFDNWL QGHGRYPSTG ILSVIFSMHV CDEVDLYGFG ADSKGNWHHY WENNPSAGAF RKTGVHDADF ESNVTATLAS INKIRIFKGR
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