About CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3) is a protein
from Homo sapiens identified by UniProt accession
Q11203, 375 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase |
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| UniProt accession | Q11203 |
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| Gene | ST3GAL3 |
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| Organism | Homo sapiens |
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| Length | 375 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- West syndrome · score 0.73
- autosomal recessive non-syndromic intellectual disability · score 0.72
- developmental and epileptic encephalopathy · score 0.55
- COVID-19 · score 0.46
- neurodegenerative disease · score 0.44
- genetic disorder · score 0.41
- developmental disorder of mental health · score 0.37
- severe acute respiratory syndrome · score 0.37
- alkaline phosphatase measurement · score 0.36
- intelligence · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q11203-F1 | alphafold | PREDICTED | 90.92 | — |
Amino-acid sequence (375 residues)
MGLLVFVRNL LLALCLFLVL GFLYYSAWKL HLLQWEEDSN SVVLSFDSAG QTLGSEYDRL GFLLNLDSKL PAELATKYAN FSEGACKPGY ASALMTAIFP RFSKPAPMFL DDSFRKWARI REFVPPFGIK GQDNLIKAIL SVTKEYRLTP ALDSLRCRRC IIVGNGGVLA NKSLGSRIDD YDIVVRLNSA PVKGFEKDVG SKTTLRITYP EGAMQRPEQY ERDSLFVLAG FKWQDFKWLK YIVYKERVSA SDGFWKSVAT RVPKEPPEIR ILNPYFIQEA AFTLIGLPFN NGLMGRGNIP TLGSVAVTMA LHGCDEVAVA GFGYDMSTPN APLHYYETVR MAAIKESWTH NIQREKEFLR KLVKARVITD LSSGI
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