About Syntaxin-4
Syntaxin-4 (STX4) is a protein
from Homo sapiens identified by UniProt accession
Q12846, 297 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Syntaxin-4 |
|---|
| UniProt accession | Q12846 |
|---|
| Gene | STX4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 297 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (156)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- Sensorineural hearing impairment · score 0.26
- sensorineural hearing loss · score 0.26
- thyroid gland adenocarcinoma · score 0.23
- breast adenocarcinoma · score 0.23
- Hearing impairment · score 0.18
- ovarian carcinoma · score 0.18
- acute myeloid leukemia · score 0.17
- colorectal carcinoma · score 0.15
- gastric carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12846-F1 | alphafold | PREDICTED | 78.03 | — |
Amino-acid sequence (297 residues)
MRDRTHELRQ GDDSSDEEDK ERVALVVHPG TARLGSPDEE FFHKVRTIRQ TIVKLGNKVQ ELEKQQVTIL ATPLPEESMK QELQNLRDEI KQLGREIRLQ LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNSMQSEYRE KNVERIRRQL KITNAGMVSD EELEQMLDSG QSEVFVSNIL KDTQVTRQAL NEISARHSEI QQLERSIREL HDIFTFLATE VEMQGEMINR IEKNILSSAD YVERGQEHVK TALENQKKAR KKKVLIAICV SITVVLLAVI IGVTVVG
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