About Inositol 1,4,5-triphosphate receptor associated 2
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) is a protein
from Homo sapiens identified by UniProt accession
Q12912, 555 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Inositol 1,4,5-triphosphate receptor associated 2 |
|---|
| UniProt accession | Q12912 |
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| Gene | IRAG2 |
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| Organism | Homo sapiens |
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| Length | 555 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- nasopharyngeal neoplasm · score 0.27
- lung adenocarcinoma · score 0.06
- metabolite measurement · score 0.05
- sphingomyelin measurement · score 0.04
- parasitic infection · score 0.02
- neoplasm · score 0.02
- cancer · score 0.01
- chronic lymphocytic leukemia · score 0.01
- gastric carcinoma · score 0.01
- type 1 diabetes mellitus · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12912-F1 | alphafold | PREDICTED | 58.17 | — |
Amino-acid sequence (555 residues)
MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN LSGCIRMNDD PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS SDPGLEILNM ASCDLDRNSL CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD STSKDKTILN LEAKEEPETI EEHKKEHASG DSVVSPLPVT TVKSVNLRQS ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD LAEENLKKEI TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE DDDDCQIKKR SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR RSSSWRILGS KQSEHRPSLP RFISTYSWAD AEEEKCELKT KDDSEPSGEE TVERTRKPSL SEKKNNPSKW DVSSVYDTIA SWATNLKSSI RKANKALWLS IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI LWPFTRLRHN GPPPV
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