About Secreted phosphoprotein 24
Secreted phosphoprotein 24 (SPP2) is a protein
from Homo sapiens identified by UniProt accession
Q13103, 211 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Secreted phosphoprotein 24 |
|---|
| UniProt accession | Q13103 |
|---|
| Gene | SPP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- phosphate measurement · score 0.43
- Retinal dystrophy · score 0.35
- blood phosphate measurement · score 0.31
- adolescent idiopathic scoliosis · score 0.30
- white matter microstructure measurement · score 0.26
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.14
- triglyceride measurement · score 0.14
- hip bone size · score 0.14
- esophageal cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13103-F1 | alphafold | PREDICTED | 70.43 | — |
Amino-acid sequence (211 residues)
MISRMEKMTM MMKILIMFAL GMNYWSCSGF PVYDYDPSSL RDALSASVVK VNSQSLSPYL FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP ATCAFQRDYY VSTAVCRSTV KVSAQQVQGV HARCSWSSST SESYSSEEMI FGDMLGSHKW RNNYLFGLIS DESISEQFYD RSLGIMRRVL PPGNRRYPNH RHRARINTDF E
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