About Deleted in azoospermia protein 2
Deleted in azoospermia protein 2 (DAZ2) is a protein
from Homo sapiens identified by UniProt accession
Q13117, 558 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Deleted in azoospermia protein 2 |
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| UniProt accession | Q13117 |
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| Gene | DAZ2 |
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| Organism | Homo sapiens |
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| Length | 558 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (135)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 1 · score 0.08
- spermatogenic failure 48 · score 0.07
- primary ovarian insufficiency · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 22 · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13117-F1 | alphafold | PREDICTED | 73.05 | — |
Amino-acid sequence (558 residues)
MSAANPETPN STISREASTQ SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC ARHVQPRPLV VNPPPPPQFQ NVWRNPNTET YLQPQITPNP VTQHVQAYSA YPHSPGQVIT GCQLLVYNYQ EYPTYPDSAF QVTTGYQLPV YNYQPFPAYP RSPFQVTAGY QLPVYNYQAF PAYPNSPFQV ATGYQFPVYN YQPFPAYPSS PFQVTAGYQL PVYNYQAFPA YPNSPFQVAT GYQFPVYNYQ AFPAYPNSPV QVTTGYQLPV YNYQAFPAYP NSPVQVTTGY QLPVYNYQAF PAYPSSPFQV TTGYQLPVYN YQAFPAYPSS PFQVTTGYQL PVYNYQAFPA YPSSPFQVTT GYQLPVYNYQ AFPAYPSSPF QVTTGYQLPV YNYQAFPAYP SSPFQVTTGY QLPVYNYQAF PAYPSSPFQV TTGYQLPVYN YQAFPAYPNS AVQVTTGYQF HVYNYQMPPQ CPVGEQRRNL WTEAYKWWYL VCLIQRRD
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