About Syntaxin-5
Syntaxin-5 (STX5) is a protein
from Homo sapiens identified by UniProt accession
Q13190, 355 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Syntaxin-5 |
|---|
| UniProt accession | Q13190 |
|---|
| Gene | STX5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 355 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.14
- breast adenocarcinoma · score 0.10
- retinitis pigmentosa · score 0.08
- hepatocellular carcinoma · score 0.07
- age-related macular degeneration · score 0.07
- Familial exudative vitreoretinopathy · score 0.07
- X-linked retinal dysplasia · score 0.07
- Leber congenital amaurosis · score 0.06
- Cone rod dystrophy · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13190-F1 | alphafold | PREDICTED | 70.36 | — |
Amino-acid sequence (355 residues)
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVTLVPP PPDTMSCRDR TQEFLSACKS LQTRQNGIQT NKPALRAVRQ RSEFTLMAKR IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESHAS KDVAIDMMDS RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF VVFLA
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