Serine/arginine-rich splicing factor 5 (SRSF5)

About Serine/arginine-rich splicing factor 5

Serine/arginine-rich splicing factor 5 (SRSF5) is a protein from Homo sapiens identified by UniProt accession Q13243, 272 residues long. MolForge cross-references it against 0 known binders and 177 disease associations.

Target properties

Protein name	Serine/arginine-rich splicing factor 5
UniProt accession	Q13243
Gene	SRSF5
Organism	Homo sapiens
Length	272 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (177)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
erythrocyte count · score 0.29
mean corpuscular volume · score 0.23
mean reticulocyte volume · score 0.21
platelet crit · score 0.13
mean corpuscular hemoglobin · score 0.12
lean body mass · score 0.07
hypertrophic cardiomyopathy · score 0.07
Arrhythmogenic right ventricular dysplasia · score 0.06
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13243-F1	alphafold	PREDICTED	64.01	—

Amino-acid sequence (272 residues)

MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHSRSRSRS RSRTRSSSRS RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ KRGSSSRSKS PASVDRQRSR SRSRSRSVDS GN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards