Serine/arginine-rich splicing factor 6 (SRSF6)

About Serine/arginine-rich splicing factor 6

Serine/arginine-rich splicing factor 6 (SRSF6) is a protein from Homo sapiens identified by UniProt accession Q13247, 344 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Serine/arginine-rich splicing factor 6
UniProt accession	Q13247
Gene	SRSF6
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (123)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.33
body mass index · score 0.21
mathematical ability · score 0.20
self reported educational attainment · score 0.19
mood instability measurement · score 0.18
smoking status measurement · score 0.18
lymphocyte count · score 0.16
body fat percentage · score 0.16
seropositivity measurement · score 0.16
Chlamydia pneumoniae seropositivity · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13247-F1	alphafold	PREDICTED	62.58	—

Amino-acid sequence (344 residues)

MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards