About Syntaxin-3
Syntaxin-3 (STX3) is a protein
from Homo sapiens identified by UniProt accession
Q13277, 289 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Syntaxin-3 |
|---|
| UniProt accession | Q13277 |
|---|
| Gene | STX3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 289 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- retinal dystrophy and microvillus inclusion disease · score 0.57
- microvillus inclusion disease · score 0.47
- diarrheal disease · score 0.37
- acute myeloid leukemia · score 0.24
- genetic disorder · score 0.19
- sex hormone-binding globulin measurement · score 0.16
- body height · score 0.12
- IGF-1 measurement · score 0.12
- breast milk measurement · score 0.10
- esophageal squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13277-F1 | alphafold | PREDICTED | 83.30 | — |
Amino-acid sequence (289 residues)
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN
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